Coley's Toxins (Mixed Bacterial Vaccine) therapy for the treatment of cancer

Therapy | Treatment

Coley Vaccine (Mixed Bacterial
Vaccine) therapy

Immunotherapy treatment for cancer by fever therapy.

Background

Coley Vaccine (Mixed Bacterial Vaccine), also known as Coley's Toxins or Coley Fluid (CF) is a treatment originally developed by a surgeon named William Coley in 1893. The treatment consisted of a sterile mixture of gram-positive Streptococcus pyogenes and gram-negative Serratia marcescens bacteria. Using a killed bacterial suspension, Coley could mimic an infection (producing chills and fever) and accompanying immune response, without incurring the risks of an actual infection.

Mechanism of Action

Coley advised that Coley Vaccine was most effective when administered daily, when a fever was repeatedly induced, and when the treatment was continued (at less frequent intervals) well past clinical regression to prevent recurrence.

It has been found that solid tumors often show a high degree of leukocyte infiltration. Even micrometastates have been shown to have a high content of infiltrating leukocytes. These tumor-infiltrating leukocytes (TILs) consist of heterogeneous populations of cells, including varying proportions of neutrophils, macrophages, T and B cells, and natural killer cells. As tumors expand, cytokines are released signaling an increasing need for oxygen and nutrients. It has been proposed that leukocytes, which are also involved in tissue repair, become attracted to growing malignant lesions through the release of these signaling molecules or chemokines, and assume their normal reparative activities such as expanding the vascular network and stimulating tissue regrowth. Recent evidence supports the theory that tumors grow with the assistance, rather than the antagonism, of the immune system. So the administration of Coley's Toxins is designed to reactivate the defensive activities of these TILs. Active stimulation of TILs by Coley's Vaccine has been suggested by the frequent observation of inflammation of malignant lesions soon after Coley Fluid injection.

Coley Vaccine therapy

  • Coley Vaccine therapy is administered about 3-5 times per week at a dose which achieves a body temperature of between 39.5 °C to 41 °C (approximately 103 °C to 106 °F), while being monitored by qualified medical staff.
  • The exact number of treatments per week may vary depending on each individual patient and other circumstances.
  • Patients generally receive one infusion per day.
  • About 5-6 hours of treatment are required for each treatment day.
  • Vital signs (blood pressure, heart rate, respiratory rate, temperature) are constantly monitored by professional and experienced medical staff.
  • Coley Vaccine has a very long and safe history of use.
  • Generally patients experience improved wellbeing after each treatment.
  • This treatment is ideally used in conjunction with other immunotherapies, such as GcMAF macrophage activating factor and Maitake MD-fraction.

Low-dose Coley Vaccine therapy (Gentle Coley's)

  • Low-dose Coley Vaccine treatment is used to stimulate the immune system using low doses of Coley Vaccine, which have minimal side effects such as shivers and fever. This treatment is ideal in conjunction with other immunotherapies, such as GcMAF macrophage activating factor and Maitake MD-fraction.
  • Treatment time is significantly less than regular Coley Vaccine therapy, taking about 1-2 hours.
  • May be used before starting regular Coley Vaccine therapy.

Treatments commonly used in conjunction with Coley's Vaccine Therapy

GcMAF therapy
High Dose GcMAF therapy
Maitake MD-fraction
Maitake MD-fraction
Hyperbaric oxygen therapy
Hyperbaric oxygen therapy
Ozone therapy
Ozone therapy

Cost

Coley Vaccine therapy:

  • 30 times - 1,000,000 yen *
  • Treatment does not include cost of blood tests.
  • 3 to 5 days of treatment per week. The number of treatments per week may vary depending on each individual patient and other circumstances.

Low-dose Coley Vaccine therapy:

  • 1 time treatment - 10,000 yen *
  • 10 times treatment - 80,000 yen *
  • Treatment does not include cost of blood tests.
  • The number of treatments per week varys depending on each individual patient and other treatments being conducted.

News

Heart Pharmacy website gcmaf.co.jp is now open

Purchase your Colostrum MAF here using PayPal or credit card.

→ Heart Pharmacy website


2016 Integrative Medical Therapies Conference - Osaka, Japan

Thank you very much for your participation at the Saisei Mirai 2016 Integrative Medical Therapies conference in Osaka, held on Sunday 13th November 2016.

→ 2016 Integrative Medical Therapies conference - Osaka, Japan


Genostics Conference - Sydney, Australia

24-SEP-2016
Dr Toshio Inui

→ Genostics official website


Symposium on Integrated Medicine: Electric Fields Therapy & Immunotherapy - Jakarta, Indonesia


22-JUL-2016
Dr. Toshio Inui gave a presentation of the electric field therapy and second-generation GcMAF and colostrum MAF at a conference which was held in Jakarta, Indonesia on July 22, 2016.



International Pharmacy Conference

14 to 15-JUL-2016
Dr. Shinichiro Akiyama at International Pharmacy Conference, which was held in the United States Philadelphia, Pennsylvania on July 14 to 15, 2016, the Clinical experience of colostrum derived protein against solid cancer has been announced as the Keynote Speaker.



New New research papers published by Saisei Mirai in Anticancer Research available online.

Research paper
2016 Case Report: GcMAF Treatment in a Patient with Multiple Sclerosis (PDF)
ANTICANCER RESEARCH 36: 3771-3774 (2016)

Case Report: GcMAF Treatment in a Patient with Multiple Sclerosis Case Report: GcMAF Treatment in a Patient with Multiple Sclerosis Case Report: GcMAF Treatment in a Patient with Multiple Sclerosis

Research paper
2016 Case Report: A Non-small Cell Lung Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Tumor Treating Fields (PDF)
ANTICANCER RESEARCH 36: 3767-3770 (2016)

Case Report: A Non-small Cell Lung Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Tumor Treating Fields Case Report: A Non-small Cell Lung Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Tumor Treating Fields Case Report: A Non-small Cell Lung Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Tumor Treating Fields

Research paper
2016 Macrophages Exhibit a Large Repertoire of Activation States via Multiple Mechanisms of Macrophage-activating Factors (PDF)
ANTICANCER RESEARCH 36: 3619-3624 (2016)

Macrophages Exhibit a Large Repertoire of Activation States via Multiple Mechanisms of Macrophage-activating Factors Macrophages Exhibit a Large Repertoire of Activation States via Multiple Mechanisms of Macrophage-activating Factors Macrophages Exhibit a Large Repertoire of Activation States via Multiple Mechanisms of Macrophage-activating Factors

New research papers published by Saisei Mirai in Anticancer Research available online.

New research papers on Oral Colostrum GcMAF for Chronic Fatigue Syndrome (CFS) and serious infection published in Anticancer Research journal.

Research paper
2015 Oral Colostrum Macrophage-activating Factor for Serious Infection and Chronic Fatigue Syndrome: Three Case Reports (PDF)
Anticancer Res August 2015 35 (8) 4545-4549

Conference presentation - 10th International Congress for Medical Laser Applications, Germany

13-JUN-2015
Clinical application of Second Generation GcMAF and oral GcMAF
Dr Toshio Inui

Clinical application of Second Generation GcMAF and oral GcMAF
ISLA website

Conference presentation - 9th International Congress for Medical Laser Applications, Germany

29-JUN-2014
Indications for GcMAF for immunotherapy of cancers and chronic viral and bacterial infections (PDF)

Dr Toshio Inui

Dr Toshio Inui Indications for GcMAF for immunotherapy of cancers and chronic viral and bacterial infections

Conference presentation - The 17th Annual Meeting of The Society of Biotherapeutic Approaches, Fukuoka University

7-DEC-2013
Case Report: A Breast Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Hormone Therapy (PDF), PPT

Dr Toshio Inui

Dr Toshio Inui Case Report - A Breast Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Hormone Therapy

New research papers published by Saisei Mirai in Anticancer Research available online.

New research papers on GcMAF and integrative cancer immunotherapy treatment written in collaboration with the University of Tokushima, Kanazawa University and Kobe University Graduate School of Medicine researchers and Saisei Mirai published in Anticancer Research journal.

Research paper
2013 Degalactosylated/Desialylated Human Serum Containing GcMAF Induces Macrophage Phagocytic Activity and In Vivo Antitumor Activity (PDF)
Anticancer Res July 2013 33 (7) 2881-2885

Cancer vaccine therapy - autologous tissue derived tumor vaccine Cancer vaccine therapy - autologous tissue derived tumor vaccine Cancer vaccine therapy - autologous tissue derived tumor vaccine

Research paper
2013 Clinical Experience of Integrative Cancer Immunotherapy with GcMAF (PDF)
Anticancer Res July 2013 33 (7) 2917-2919

Cancer vaccine therapy - autologous tissue derived tumor vaccine Cancer vaccine therapy - autologous tissue derived tumor vaccine Cancer vaccine therapy - autologous tissue derived tumor vaccine

Nature Outlook sponsored article

For more details on GcMAF see our GcMAF page.



Experiment report of Gc MAF stability assay
14-JUN-2012 Stability of GcMAF in Serum (PDF)
H Mukai, Y Uto. Department of Biological Science and Technology, The University of Tokushima.

Stability of GcMAF in Serum report Stability of GcMAF in Serum report

The results show that 2nd Generation GcMAF is stable for 1 year at 4 °C, for 14 days at room temperature (around 20 °C), and for 7 days at 40 °C.

See Research and references for more details on experiments on macrophage phagocytic activity and stability of our GcMAF.


Collaborations with the University of Tokushima
We collaborate with GcMAF researchers at the University of Tokushima, Japan in the development of second generation GcMAF. See Research and references for published research papers on Gc-MAF in peer-reviewed scientific journals authored by the University of Tokushima researchers over the last decade. Our research on GcMAF is ongoing and papers are being prepared for publication in collaboration between the University of Tokushima and Saisei Mirai in the next few months.


University of Tokushima, Institute of Technology and Science, Laboratory Research

Our research group:

Imagin-K

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