To assist in the treatment of cancer, HIV, Hepatitis and immune system diseases.
Maitake: King of Mushrooms
Maitake (scientific name Grifola frondosa) is indigenous to the northeastern part of Japan. In Japan, Maitake can grow to more than 20 kilograms in size, earning this giant mushroom the title King of Mushrooms. Maitake is so named, not only for its large size but also for its amazing health benefits. Apart from it’s health benefits, it is also highly sought after for it’s excellent taste.
Medicinal mushroom derived β-glucans are notable for their ability to modulate the immune system. Sources of beta-glucan include various species of mushrooms, such as reishi, shiitake, and maitake. β-Glucans are known as “biological response modifiers” because of their ability to activate the immune system. Immunologists have discovered that receptors on the surface of innate immune cells called dectin-1 and complement receptor 3 (CR3 or CD11b/CD18) are responsible for binding to β-glucans, allowing the immune cells to recognize them.
Maitake MD-Fraction – the original from JapanMaitake beta-glucan MD-Fraction is the original patented product which is made in Japan to ISO standards.
A phase I/II human trial, conducted by Memorial Sloan?Kettering Cancer Center, showed Maitake could stimulate the immune system of breast cancer patients. Small experiments with human cancer patients, have shown Maitake can stimulate immune system cells like NK cells. In vitro research has also shown that Maitake can stimulate immune system cells, confirming the clinical experiments in humans.
Small studies with human cancer patients revealed that the Maitake D-fraction portion of the Maitake mushroom possess anti-cancer activity. In vitro research demonstrated that Maitake has potential anti-metastatic properties. In 1997, the US Food and Drug Administration (FDA) approved an Investigational New Drug Application for a portion of the mushroom.
Research has shown Maitake has a hypoglycemic effect, and may be beneficial for the management of diabetes. The reason Maitake lowers blood sugar is due to the fact the mushroom contains a natural alpha glucosidase inhibitor. Alpha-glucosidase inhibitors are saccharides that act as competitive inhibitors of enzymes needed to digest carbohydrates. Since cancer cells have a preference for glucose, lowering blood sugar levels in cancer patients tends to produce beneficial effects for the patient. Clinical studies in cancer patients with Metformin, a common anti-diabetic drug, show similar beneficial effects.
Maitake contains antioxidants and may partially inhibit the enzyme cyclooxygenase. An experiment showed that an extract of Maitake inhibited angiogenesis via inhibition of the vascular endothelial growth factor (VEGF).